LJU-CIN-5
Actiflash
16-03-2023
The stable Tamoxifen-like photoactivable inducer to perform a spatial and temporal control of your favorite proteins under illumination
DKK 4.275,00
Categories
- Molecular Biology
- Imaging consumerables
- Nucleic Acid Purification
- PCR Enzymes
- RT-PCR Enzymes
- NGS
- Chromogenic Microbial Media
- General Microbial Media
- Fine Chemicals
- Homogenization Instruments
- Homogenization Consumables
Description
Actiflash is a tamoxifen-like caged-inducer, called cyclofen, that enables, upon photoactivation, the fast releasing of proteins fused to the modified estrogen receptor ligand-binding domains, ERT2. Optical-induced uncaging of Actiflash releases the fusion proteins, allowing them to translocate into the nucleus, activate transcription (using Gal4-UAS system) or induce recombination (using the Cre-lox one).
The protein expression can thus be simply controlled in time and space thanks to UV-light.
Actiflash is a great R&D tool to convert your inducible ERT model into a photo-inducible one. It is very helpful if you want to control transcription (using Gal4-UAS) or induce recombination (using Cre-lox) in space and/or time for in-vivo cell tracking experiments and more.
Visit our glossary for a definition of Tamoxifen.
A technology designed by Ludovic Jullien , Isabelle Aujard and Thomas Le Saux
Published in ChemBioChem
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